Senior Scientist, Expression Sciences (Norristown)


: $81,640.00 - $118,940.00 /year *

Employment Type

: Full-Time


: Scientific Research

Job Description

Janssen Research & Development, L.L.C., a division of Johnson & Johnson's Family of Companies is recruiting for a Senior Scientist, Expression Sciences located in Spring House, PA.
At the Janssen Pharmaceutical Companies of Johnson & Johnson, we are working to create a world without disease. Transforming lives by finding new and better ways to prevent, intercept, treat and cure disease inspires us. We bring together the best minds and pursue the most promising science.
We are Janssen. We collaborate with the world for the health of everyone in it. Learn more at and follow us @JanssenGlobal. Janssen Research & Development, LLC is part of the Janssen Pharmaceutical Companies.
Are you motivated by the thought of discovering the next generation of biomedicines? Are you a passionate and skilled researcher looking to work in a dynamic, fast-paced R&D environment? We at Janssen are, and we are looking for colleagues who share the same motivation and passion. We are seeking an exceptional senior scientist who will leverage molecular biology and protein expression technologies to enable discovery of multi-specific antibodies and protein scaffolds as therapeutic candidates.In this role, you will directly impact our growing biotherapeutics pipeline though several key areas of focus:
Serve as a critical link between biotherapeutics Lead Engineering and Expression Sciences to design and ensure the integrity of nucleic acid expression constructs enabling lead selection.
Lead the generation and validation of clinical manufacturing quality plasmids and transfer to manufacturing Cell Line Development.
Design and execute medium scale protein expression to enable key pipeline deliverables for mAb/protein-based therapeutics discovery.
Research and manage external protein expression resources.

Excel at implementing molecular biology processes using state-of-the-art technologies and effectively align with development teams to ensure timeline deliverables are met for lead candidates.
Effectively collaborate with multidisciplinary scientists and establishment an integral role on project and functional teams to drive project advancement, including communicating in a highly matrixed scientific environment
Possess an in-depth understanding of the biology of protein expression, vector manipulation, design of expression constructs, and recombinant DNA technologies, especially as it relates to mammalian cell culture.
Be able to quickly establish an understanding of lead biotherapeutic programs with a focus on multi-specific modalities.
Carry a passion to drive efficiency of existing processes while simultaneously working to implement and apply novel solutions to technical challenges.
Maintain accurate electronic laboratory notebooks and other records and writing of technical reports, summaries, protocols, and manuscripts.

Ph.D. in Molecular Biology or related field required
Post-doctoral training is preferred
A minimum of 3 or more years of molecular biology and protein expression experience is preferred
Experience of making various molecular constructs is required.
Understanding of protein expression and/or characterization is required
Previous experience working with external partners is preferred.
Experience with bispecific or multi-specific antibodies, novel protein therapeutics, and antibody mechanisms of action preferred.
The successful candidate should have the ability to work independently and meet aggressive metric-driven timelines.
Candidate must have good organization and excellent communication skills, the ability to collaborate within multidisciplinary teams, and demonstrated working knowledge of scientific principles.
Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.

Associated topics: drug discovery, healthcare, immuno oncology, industrial hygienist, nephrology, pharmaceutical, pharmacy, physiology, therapy, transfection * The salary listed in the header is an estimate based on salary data for similar jobs in the same area. Salary or compensation data found in the job description is accurate.

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