Scientist II - Mammalian Cell Culture Process Development

Ambrx in La Jolla, CA

  • Industry: Scientific Research - Health/Medicine/Pharmacology
  • Type: Full Time
  • Compensation: $103,730.00 - 157,700.00 / Year*
Ambrx is a biopharmaceutical company enabling a new field of protein medicinal chemistry, using a fundamentally new technology that directs incorporation of amino acids beyond nature's conserved set into biosynthetic proteins to produce high value biologics products. Ambrx is seeking a highly motivated Scientist II to be a key member of a fast-paced and dynamic organization.

Job Summary

The candidate will be responsible for developing cell culture medium, feeding strategies, process parameter optimization, and scale-up to support R&D, large scale production, pre-clinical, and clinical activities. Participation in writing development reports, protocols, batch records and technology transfer will also be required. This scientist should demonstrate strong scientific/technical and interpersonal skills as well as the ability to communicate effectively. The candidate will apply biological and engineering expertise to develop recombinant protein production processes suitable for large-scale cGMP manufacturing and acts as a mentor for those with similar or less engineering expertise, providing both technical expertise and leadership to understand potential career paths. This job may require some travel to development partners and other manufacturing sites both in and outside the US.

Requirements:
PhD with 2+ or Master's Degree with 8+ years industrial experience and a degree in Chemical Engineering or related field.
Must have hands on experience in process development utilizing CHO cells to produce biologics using spin tubes, shake flasks, and bioreactors
Knowledgeable in cell culture process scale-up and technology transfer to contract manufacturing organizations.
Must have a proven record of innovation and have the ability to apply scientific and engineering principles to solve complex problems.
A good understanding of cell physiology, metabolism, and cell biology
Ability to multitask and adapt in a fast paced environment and stay focused on project
deliverables.
Work with minimum supervision in designing and executing experiments and analyzing data.

Additional Desired Experience and Skills:
Knowledge of Design of Experiments (DOE) and statistical analysis of data.
Working knowledge of GMPs and experience writing SOPs and batch records.
Medium development experience for CHO cell culture
Experience with pilot scale bioreactors and primary recovery equipment.
Associated topics: aseptic technique, biopharma, biopharmaceutical, clinical, dietetic, food scientist, histology, microbiological, pharmaceutical, pharmacometrics

* Estimated salary


You may be interested in these similar jobs near La Jolla, CA!

Scientist II Mammalian Cell Culture Process Development
Ambrx

Scientific Opportunity with San Diego Biopharmaceutical Ambrx, Inc.Scientist II - Mammalian Cell Culture Process Development(Job Code: 11b 20BR)Ambrx…

Read More
Principal Scientist, Mammalian Cell Culture Development
Ambrx

Ambrx is a clinical?stage biopharmaceutical company enabling a new field of protein medicinal chemistry, using a technology that directs the incorpor…

Read More
Senior Scientist, Manufacturing Science and Technology
Fate Therapeutics

Fate Therapeutics is seeking an experienced and highly motivated cell therapy process development professional to develop manufacturing processes for…

Read More
Senior Scientist, Molecular Biology, BioMedicine Design
Pfizer

**Senior Scientist - Protein Expression and Molecular Biology** BioMedicine Design (BMD) is seeking a highly motivated scientist to be part of the pr…

Read More
Cell Biology Scientist
Iconma, L.L.C.

Cell Biology ScientistLocation: Carlsbad, CADuration: 12 monthsDescription:Key Responsibilities:Isolate Genomic DNA from various sources including bl…

Read More
Process Development Scientist - Upstream
Abzena

Job Description Overall Responsibilities:Executes assigned work with full understanding of and ability to apply principles, theories, and concepts in…

Read More
Senior Scientist / Scientist, Quality Control - Analytical Development
Fate Therapeutics

Fate Therapeutics is seeking a motivated Quality Control scientist with multicolor flow cytometry experience to support Fate's manufacturing programs…

Read More
Senior Associate Scientist, Molecular Biology and Protein Expression
Pfizer

**ROLE SUMMARY** BioMedicine Design (BMD) is seeking a highly motivated scientist to join a protein expression and molecular biology group supportin…

Read More
Senior Process Development Engineer
Fate Therapeutics

Fate Therapeutics is seeking an experienced and highly motivated cell therapy process development professional to lead scale-up and cGMP-compliant pr…

Read More
Scientist, Molecular Biology and Protein Expression
Pfizer

BioMedicine Design (BMD) is seeking a highly motivated scientist to be part of the protein expression and molecular biology group supporting the Biot…

Read More