QSP SCIENTIST LAWRENCEVILLE, NJ Project Description: The scientist in this role will work in the Quantitative Systems Pharmacology (QSP) group to further develop established disease-level QSP models and apply them to support decisions in clinical development. This will include QSP model development, QSP model application, and will also include developing improvements to scripted QSP toolboxes through refinement and addition of virtual population calibration algorithms, global sensitivity analysis tools, and the development of additional functions for common workflows to make their application more robust. The scientist may also work on parameter estimation, machine learning, omics data analysis strategies, development of mechanistic sub-models, and improving integration with high-throughput computing resources as needed. Providing support to project teams to design, execute and interpret clinical studies . Improvement of QSP tools to enhance the efficiency of QSP algorithms and workflows . Collaboration with multidisciplinary project teams to develop and apply Quantitative Systems Pharmacology models to aid in target prioritization, therapeutic modality selection, chemical/biotherapeutic optimization, biomarker characterization and clinical trial design . Working with external collaborators to accelerate the internal QSP efforts . Maintaining an active relationship with colleagues in the broader Clinical Pharmacology & Pharmacometrics community at Client. Networking as appropriate with experts in Discovery Biology, Non-Clinical PK/PD and other groups to share learnings and enhance consistency in best practices . Participate in internal scientific discussions to enhance QSP algorithms and workflows . Drive the development of QSP disease models in Immuno-Oncology . Required Skills: 5 years QSP modeling experience wanted. 2 year minimum. MATLAB or SimBiology experience are required (writing codes). Sensitivity analysis experience required . Ph.D. (or M.S. with 5 more years' experience) in mathematics, engineering, physics, computer science or other related field, with at least 2 years in Pharmaceutical R&D. Excellent understanding of theory, principles and statistical aspects of advanced mathematical modeling and simulation . Ability to learn new areas of biological sciences and build on solid foundation of quantitative skills to develop Quantitative Systems Pharmacology models . Ability to keep up-to-date with and propose the implementation of scientific and technological developments in the area of Systems Pharmacology/Biology . Hands-on experience with modeling software like JDesigner/Systems Biology Workbench, Entelos PhysioLab Platform, Matlab/SimBiology, DBSolve, etc. Experience with mechanistic model development in SimBIology would be preferable. Experience with general programming and data analysis tools/languages such as R, Matlab, Spotfire, Python, etc. is required. Experience developing scripted tools in MATLAB is preferable. Desire to interact as a modeling and simulation expert with matrix project teams working closely with experts from different functional areas (pre-clinical and clinical) . Understanding of key concepts in oncology, pharmacology, & statistics . Candidates with experience in QSP platform application and virtual population development are highly encouraged to apply . This 12 month position starts ASAP. Please E-MAIL your resume (attachment to email) with rate and availability to Karen: karenalphaconsulting.com ALPHA'S REQUIREMENT 19-01755 W2 ONLY MUST BE ELIGIBLE TO WORK IN THE U.S. AS AN HOURLY W2 EMPLOYEE ZR - provided by Dice Associated topics: biopharma, cytometry, dietetic, histologist, industrial hygienist, medical, microbiological, pharmaceutical, pharmacometrics, physiology
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